TNF-α Protease Inhibitor-0

产品名称：

163958-73-4
TAPI-0
N-(R)-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine amide
TNF-α Protease Inhibitor-0
TNF-α Processing Inhibitor-0

产品介绍：

产品说明

包装

1 mg in glass bottle

生化/生理作用

TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). TAPI-0 also inhibits of collagenase and gelatinase. Although not specific for TACE, TAPI-0 is extensively used to block TACE-mediated TNF-α shedding.
TAPI-0 inhibit peptide deformylase (PDF) activity and retard the growth Chlamydia trachomatis, which is an obligate intracellular bacterium responsible for a number of human diseases.

基本信息

经验(实验)分子式	C₂₄H₃₂N₄O₅
分子量	456.53
MDL编号	MFCD02684279
PubChem化学物质编号	329825768
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
颜色	white to off-white
运输	wet ice
储存温度	−20℃
SMILES string	NC([C@@](C)([H])NC([C@]([H])(CC1=CC=CC2=C1C=CC=C2)NC([C@@](CC(C)C)([H])CC(NO)=O)=O)=O)=O
InChI	1S/C24H32N4O5/c1-14(2)11-18(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-17-9-6-8-16-7-4-5-10-19(16)17/h4-10,14-15,18,20,33H,11-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,18+,20-/m0/s1
InChI key	WSJJYJNVFYARGB-CVAIRZPRSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P310 + P330
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable