产品说明
应用
Trimethoprim is used at a final concentration of ~4μg/mL for antibacterial activty.
生化/生理作用
Trimethoprim is a synthetic derivative of pyrimidine with antibacterial and antiprotozoal properties. Trimethoprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), interfering with the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is an essential precursor in the thymidine synthesis pathway, interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim′s affinity for bacterial DHFR is several thousand times greater than its affinity for human DHFR. Trimethoprim is potentiated by Sulfonamides and the Trimethoprim-sulfamethazole combination is the most used form.
基本信息
| 经验(实验)分子式 | C14H18N4O3 |
| 分子量 | 290.32 |
产品性质
| 生物来源 | synthetic |
| 测定 | ≥98% (HPLC) |
| 形式 | liquid |
| 浓度 | 25 mg/mL in DMSO |
| 作用机制 | DNA synthesis | interferes enzyme | inhibits |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria mycobacteria |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F |
| 闪点(C) | 87 ℃ |
Sigma-Aldrich
m.cnreagent.com
