Caspase-8 Inhibitor II-Calbiochem

产品说明

一般描述

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.
A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

包装

250 μg in Glass bottle
1 mg in Plastic ampoule

生化/生理作用

Primary Target
caspase-8
Product does not compete with ATP.
Cell permeable: yes
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.

分析说明

single spot by TLC

其他说明

Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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产品性质

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