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位置:首页 > 品牌 > Sigma-Aldrich > Phorbol-12,13-dibutyrate-CAS 37558-16-0-Calbiochem

Phorbol-12,13-dibutyrate-CAS 37558-16-0-Calbiochem

品牌
Sigma-Aldrich
CAS
37558-16-0
货号
524390
规格纯度
Strong irritant for mouse skin, but only moderately active as a tumor promoter.
参考价格
1296.97 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
37558-16-0
Phorbol-12,13-dibutyrate-CAS 37558-16-0-Calbiochem
PDBu, PKC Activator II
产品介绍:

产品说明

一般描述

Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na+-K+ ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 µM in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.

包装

1, 5 mg in Alu drum
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Na+,K+- ATPase
Reversible: no
Cell permeable: no

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

制备说明

Further dilute with aqueous buffers just prior to use.

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Fisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
Lee, E.J., et al. 1994. Brain Res. 665, 127.
Critz, S.D., et al. 1993. J. Neurochem.60, 1175.
Iredale, P.A., et al. 1993. Biochem. Pharmacol.45, 611.
Critz, S.D., and Byrne J.H. 1992. J. Neurophys.68, 1079.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol.24, 937.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C28H40O8
分子量504.61
MDL编号MFCD00036783

产品性质

质量水平100
测定≥99% (HPLC)
形式solid (crystalline)
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色clear
溶解性DMSO: 10 mg/mL
运输ambient
储存温度−20℃
InChI1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
InChI keyBQJRUJTZSGYBEZ-YVQNUNKESA-N

安全信息

象形图GHS05GHS06GHS08
警示用语:Danger
危险声明H300 + H310 + H330 - H314 - H317 - H334 - H351
预防措施声明P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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