Glycogen Phosphorylase Inhibitor-CAS 648926-15-2-Calbiochem

产品说明

一般描述

A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC₅₀ = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC₅₀ = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Glycogen phosphorylase
Target IC₅₀: 53 nM against glycogen phosphorylase
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Klabunde, T., et al. 2005. J. Med. Chem.48, 6178

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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