产品说明
一般描述
Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.
应用
Gc-globulin from human plasma has been used:
生化/生理作用
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].
制备说明
Native Gc-globulin from human plasma
基本信息
MDL编号 | MFCD00131143 |
NACRES | NA.61 |
产品性质
质量水平 | 200 |
生物来源 | human plasma |
测定 | ≥90% (SDS-PAGE) |
形式 | lyophilized powder (containing sodium chloride and sodium phosphate buffer salt) |
分子量 | ~52 kDa |
technique(s) | LC/MS: suitable |
溶解性 | H2O: soluble 2 mg/mL |
UniProt登记号 | P02774 |
储存温度 | −20℃ |
Gene Information | human ... GC(2638) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich