产品说明
应用
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).
β-Nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium salt has been used in the Griess reagent assay of culture medium to reduce nitrate to nitrite and in glutathione peroxidase assay.
生化/生理作用
β-烟酰胺腺嘌呤二核苷酸 2′-磷酸盐 (NADP +) 和 β-烟酰胺腺嘌呤二核苷酸 2′-还原磷酸盐 (NADPH) 包含辅酶氧化还原对 (NADP + ：NADPH)，参与广泛的酶催化氧化还原反应。NADP + /NADPH 氧化还原对促进合成代谢反应中的电子转移，如脂质和胆固醇生物合成和脂肪酰基链的延长。NADP + /NADPH 氧化还原对被用于多种抗氧化机制，在该机制中可防止活性氧化物质积聚。NADPH 在体内通过磷酸戊糖途径 (PPP) 生成 。
制备说明
化学还原
其他说明
根据 UV-Vis 测定的 NADPH 含量包装。
基本信息
| 经验(实验)分子式 | C21H26N7Na4O17P3 |
| 分子量 | 833.35 |
| EC 号 | 214-664-6 |
| MDL编号 | MFCD00036263 |
| PubChem化学物质编号 | 24897841 |
| NACRES | NA.51 |
产品性质
| 质量水平 | 200 |
| 测定 | ~95% |
| 形式 | powder |
| 包装 | vial of 10 mg |
| InChI | 1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11+,13-,14+,15-,16+,20-,21+;;;;/m0..../s1 |
| InChI key | WYWWVJHQDVCHKF-MPUNMZHWSA-J |
Sigma-Aldrich
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