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5-Fluoroisatin

5-氟靛红

品牌
Sigma-Aldrich
CAS
443-69-6
货号
366978
包装型号
规格纯度
98%
参考价格
434.26 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
443-69-6
5-Fluoroisatin
NSC 39161
5-Fluoro-2,3-indoledione
5-氟靛红
产品介绍:

产品说明

一般描述

5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).

应用

Reactant for preparation of:

  • Spiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds
  • Potential antimycobacterial agents
  • Inhibitors of c-Met kinase
  • Inhibitors of TAK1 kinase
  • Herpes simplex virus inhibitors
  • IKKβ inhibitors
  • Inhibitors of vitiligo disease
  • Potential drug candidates with anti-HIV activity and anti-tubercular activity

5-Fluoroisatin may be used:
  • as reaction-based probe for live-cell detection of peroxynitrite by 19F magnetic resonance spectroscopy
  • in non-invasive detection of peroxynitrite (ONOO(-)) formation in living lung epithelial cells stimulated with interferon-γ (IFN-γ)
  • in the synthesis of bis-Schiff bases, via condensation with aromatic primary bis-amines in water suspension medium without using any organic solvent or acid catalyst
  • in the synthesis of 3-acetonyl-5-fluoro-3-hydroxyoxindole

包装

5 g in glass bottle

基本信息

经验(实验)分子式C8H4FNO2
分子量165.12
MDL编号MFCD00022795
PubChem化学物质编号24862375

产品性质

质量水平100
测定98%
mp224-227 ℃ (lit.)
SMILES stringFc1ccc2NC(=O)C(=O)c2c1
InChI1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
InChI keyGKODDAXOSGGARJ-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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