产品说明
应用
Clofibrate has been used:
包装
250 mg in glass bottle
1, 5, 10 g in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.
生化/生理作用
Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.
特点和优势
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
基本信息
| 经验(实验)分子式 | C12H15ClO3 |
| 分子量 | 242.70 |
| Beilstein | 1913459 |
| EC 号 | 211-277-4 |
| MDL编号 | MFCD00000615 |
| PubChem化学物质编号 | 24278085 |
| NACRES | NA.77 |
产品性质
| 形式 | liquid |
| 质量水平 | 200 |
| 颜色 | clear colorless |
| 密度 | 1.14 g/mL at 25 ℃ (lit.) |
| 创始人 | Wyeth |
| 储存温度 | 2-8℃ |
| SMILES string | CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 |
| InChI | 1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3 |
| InChI key | KNHUKKLJHYUCFP-UHFFFAOYSA-N |
| Gene Information | human ... PPARA(5465) mouse ... Ppara(19013) |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H315 - H318 - H335 |
| 预防措施声明 | P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | 235.4 °F - closed cup |
| 闪点(C) | 113 ℃ - closed cup |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
Sigma-Aldrich
m.cnreagent.com
