产品说明
应用
Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.
包装
1, 5, 25 g in poly bottle
生化/生理作用
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
基本信息
| 线性分子式 | C6H5C6H3(F)CH(CH3)CO2H |
| 分子量 | 244.26 |
| EC 号 | 225-827-6 |
| MDL编号 | MFCD00079303 |
| PubChem化学物质编号 | 24894968 |
产品性质
| 质量水平 | 100 |
| 生物来源 | synthetic |
| 测定 | ≥98.5% (HPLC) |
| 形式 | powder |
| 颜色 | white to off-white |
| mp | 110-112 ℃ (lit.) |
| 溶解性 | methanol: 50 mg/mL |
| 作用机制 | enzyme | inhibits |
| 抗生素抗菌谱 | fungi |
| SMILES string | CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2 |
| InChI | 1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) |
| InChI key | SYTBZMRGLBWNTM-UHFFFAOYSA-N |
| Gene Information | human ... ALB(213), APP(351), CYP1A2(1544), CYP2C9(1559), PTGS1(5742), PTGS2(5743) rat ... Ptgs1(24693) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 |
| 预防措施声明 | P264 - P270 - P301 + P310 + P330 - P405 - P501 |
| 危险分类 | Acute Tox. 3 Oral |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
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