您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > (±)-2-氟-α-甲基-4-联苯基乙酸

Flurbiprofen

氟比洛芬

品牌
Sigma-Aldrich
CAS
5104-49-4
货号
F8514
规格纯度
cyclooxygenase inhibitor
参考价格
1237.7 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
5104-49-4
Flurbiprofen
L-790,330
(±)-2-Fluoro-α-methyl-4-biphenylacetic acid
氟比洛芬
(±)-2-氟-α-甲基-4-联苯基乙酸
产品介绍:

产品说明

应用

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.

包装

1, 5, 25 g in poly bottle

生化/生理作用

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

基本信息

线性分子式C6H5C6H3(F)CH(CH3)CO2H
分子量244.26
EC 号225-827-6
MDL编号MFCD00079303
PubChem化学物质编号24894968

产品性质

质量水平100
生物来源synthetic
测定≥98.5% (HPLC)
形式powder
颜色 white to off-white
mp110-112 ℃ (lit.)
溶解性methanol: 50 mg/mL
作用机制enzyme | inhibits
抗生素抗菌谱fungi
SMILES stringCC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI keySYTBZMRGLBWNTM-UHFFFAOYSA-N
Gene Informationhuman ... ALB(213), APP(351), CYP1A2(1544), CYP2C9(1559), PTGS1(5742), PTGS2(5743)
rat ... Ptgs1(24693)

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 + P330 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Sigma-Aldrich

推荐产品