Fmoc-Asp(CSY)-OH

产品名称：

2379679-90-8
Fmoc-Asp(CSY)-OH
(S,Z)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-carboxy-1-cyano-1-(dimethylsulfonio)but-1-en-2-olate
Asp with cyanosulfurylide (CSY)-protected carboxylic acid
Fmoc-protected aspartic acid for minimized aspartimide formation

产品介绍：

产品说明

应用

Fmoc-Asp(CSY)-OH is an Fmoc-protected aspartic acid residue developed in the Bode Lab that contains a cyanosulfurylide (CSY) as a carboxylic-acid protecting group that completely suppresses aspartimide formation in peptide synthesis, a long-standing challenge in peptide chemistry that occurs during Fmoc removal or peptide coupling and affects peptide yield and sequences. Amenable to SPPS, deprotection is achieved under aqueous conditions with electrophilic halogenating agents to convert the ylide to the free acid. Furthermore, the hydrophilic nature of the ylide protecting group improves overall peptide efficiency and solubility.

其他说明

Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups

基本信息

经验(实验)分子式	C₂₃H₂₂N₂O₅S
分子量	438.50

产品性质

质量水平	100
测定	≥95%
形式	powder
mp	157-162 ℃
官能团	Fmoc
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable