Caspase-3 Inhibitor II-CAS 210344-95-9-Calbiochem

产品说明

一般描述

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.

包装

1 mg in Plastic ampoule
250 μg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

警告

Toxicity: Standard Handling (A)

序列

Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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