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Bisindolylmaleimide X hydrochloride

品牌
Sigma-Aldrich
CAS
145317-11-9
货号
B3931
包装型号
规格纯度
≥90%, solid
参考价格
1306.9 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
145317-11-9
Bisindolylmaleimide X hydrochloride
Ro 31-8425
产品介绍:

产品说明

应用

Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:

  • in chemotaxis assays
  • to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
  • in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells

生化/生理作用

Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM.

基本信息

经验(实验)分子式C26H24N4O2 · HCl
分子量460.96
MDL编号MFCD04972010
PubChem化学物质编号329773224
NACRESNA.77

产品性质

质量水平200
生物来源synthetic (organic)
测定≥90%
形式solid
溶解性DMSO: soluble
储存温度−20℃
SMILES stringCl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16
InChI1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChI keyIMBOYWXMTUUYGZ-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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