产品说明
一般描述
1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT). It is metabolized to 1-deoxyceramides.
应用
1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8+ T cells.
生化/生理作用
1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine.
包装
5 mL Amber Glass Screw Cap Vial (860493P-1mg)
5 mL Amber Glass Screw Cap Vial (860493P-10mg)
基本信息
| 经验(实验)分子式 | C18H39NO |
| 分子量 | 285.51 |
| NACRES | NA.25 |
产品性质
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (860493P-1mg) pkg of 1 × 10 mg (860493P-10mg) |
| manufacturer/tradename | Avanti Polar Lipids 860493P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | C[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
Sigma-Aldrich
m.cnreagent.com
