4′-Hydroxy carvedilol

产品名称：

142227-49-4
4′-Hydroxy carvedilol
4-(2-(3-(9H-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol
BM 14686
4′-OH carvedilol
4′-Hydroxyphenyl carvedilol
4′OH-CVD
4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol
Carvedilol metabolite M4
BM 140686
4OHC

产品介绍：

产品说明

一般描述

Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

应用

Metabolomics

基本信息

经验(实验)分子式	C₂₄H₂₆N₂O₅
分子量	422.47

产品性质

质量水平	100
测定	≥95%
形式	solid
颜色	off-white to white
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3