CHIC-35

产品名称：

848193-72-6
CHIC-35
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide
Compound (S)-35

产品介绍：

产品说明

包装

1, 5 mg in glass bottle

生化/生理作用

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC₅₀ of S-isomer is 60 nM; IC₅₀ of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC₅₀ for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₄H₁₅ClN₂O
分子量	262.73
MDL编号	MFCD11045286
PubChem化学物质编号	329775186
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (chiral, HPLC)
形式	solid
溶解性	DMSO: >10 mg/mL H₂O: <2 mg/mL
储存温度	2-8℃
SMILES string	ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
InChI	1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
InChI key	ABIVOOWWGYJNLV-JTQLQIEISA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves