Oxamflatin

产品名称：

151720-43-3
Oxamflatin
(2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid

产品介绍：

产品说明

应用

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:

to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
to study its stand-alone effect on cytarabine-sensitive and resistant cells.

包装

1, 5 mg in glass bottle

生化/生理作用

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.
Histone deacetylase inhibitor; anti-cancer agent.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₇H₁₄N₂O₄S
分子量	342.37
MDL编号	MFCD00949087
PubChem化学物质编号	329818905
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	DMSO: soluble 13 mg/mL
储存温度	2-8℃
SMILES string	ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1
InChI	1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
InChI key	QRPSQQUYPMFERG-LFYBBSHMSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)