S14161

产品名称：

883046-50-2
S14161
Pichromene
8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran
8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene

产品介绍：

产品说明

包装

1, 5 mg in glass bottle

生化/生理作用

S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.

基本信息

经验(实验)分子式	C₁₇H₁₄FNO₄
分子量	315.30
MDL编号	MFCD00112055
PubChem化学物质编号	329825969
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated protect from light
颜色	white to beige
储存温度	−20℃
SMILES string	FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2
InChI	1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
InChI key	BFZXDHIUPNWOMT-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315
危险分类	Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3