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BVT.948

品牌
Sigma-Aldrich
CAS
39674-97-0
货号
B6060
规格纯度
≥98% (HPLC), solid
参考价格
1896.74 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
39674-97-0
BVT.948
4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
产品介绍:

产品说明

包装

1 mg in glass bottle

生化/生理作用

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

特点和优势

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

基本信息

经验(实验)分子式C14H11NO3
分子量241.24
MDL编号MFCD00616487
PubChem化学物质编号24724422
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
储存条件desiccated
protect from light
under inert gas
颜色 red
溶解性DMSO: 18 mg/mL
H2O: insoluble
储存温度−20℃
SMILES stringCC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
InChI1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
InChI keyBAQXWJQSUXZVIP-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P280
危险分类Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Sigma-Aldrich

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