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Doxercalciferol

度骨化醇

品牌
Sigma-Aldrich
CAS
54573-75-0
货号
D0196
规格纯度
≥98% (HPLC), solubility: >10 mg/mL in DMSO
参考价格
1214.38 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
54573-75-0
Doxercalciferol
1α-Hydroxyergocalciferol
1α-Hydroxyvitamin D2
1α-OHD2
TSA 840
1-α-Hydroxyvitamin D2
1-Hydroxyergocalciferol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol
度骨化醇
产品介绍:

产品说明

包装

1, 5 mg in glass bottle

生化/生理作用

Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.
Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.

基本信息

经验(实验)分子式C28H44O2
分子量412.65
MDL编号MFCD00871065
PubChem化学物质编号329798592
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
溶解性DMSO: >10 mg/mL
运输wet ice
储存温度−20℃
SMILES stringCC(C)[C@@H](C)\C=C\[C@@H](C)[C@H]1CC[C@H]2C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
InChI1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChI keyHKXBNHCUPKIYDM-CGMHZMFXSA-N
Gene Informationhuman ... VDR(7421)

安全信息

象形图GHS06
警示用语:Danger
危险声明H300
预防措施声明P264 - P301 + P310
危险分类Acute Tox. 1 Oral
储存分类代码6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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