Tat-NR2B9c trifluoroacetate

产品名称：

500992-11-0
Tat-NR2B9c trifluoroacetate
NA-1, trifluoroacetate salt
YGRKKRRQRRR-KLSSIESDV, trifluoroacetate salt
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-Val, trifluoroacetate salt

产品介绍：

产品说明

生化/生理作用

Tat-NR2B9c (NA-1) is a 20-mer peptide composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 47-57) N-terminal to the NMDA receptor (NMDAR) GluN2B carboxyl tail sequence KLSSIESDV that blocks intracellular NMDAR-PSD-95 interaction-induced neurotoxic signaling without affecting NMDAR-mediated synaptic activity or calcium influx. NA-1 protects cultured cortical neurons from NMDA excitotoxicity (50 nM; 20/40/100 μM NMDA) and reduces focal ischemic brain damage in rats in vivo (3 μmol/kg iv. bolus 1 hr post MCAO onset).

基本信息

经验(实验)分子式	C₁₀₅H₁₈₈N₄₂O₃₀ · xC₂HF₃O₂
分子量	2518.88 (free base basis)

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
颜色	white to off-white
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable