Clodronate, Disodium Salt-CAS 22560-50-5-Calbiochem

产品说明

一般描述

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).
A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

包装

10 mg in Plastic ampoule

生化/生理作用

Primary Target
Osteoclast-mediated bone resorption
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target IC₅₀: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

警告

Toxicity: Standard Handling (A)

其他说明

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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