DNA Methyltransferase Inhibitor-CAS 32675-71-1-Calbiochem

品牌

Sigma-Aldrich

CAS

32675-71-1

货号

260920

包装型号

10 MG, The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure

规格纯度

The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

参考价格

3056.54 元 *本价格含增值税费

促销

数量

产品名称：

32675-71-1
DNA Methyltransferase Inhibitor-CAS 32675-71-1-Calbiochem
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I

产品介绍：

产品说明

一般描述

A cell-permeable, specific DNA methyltransferases inhibitor (IC₅₀ = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
CPG methylase M.Sssl

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Brueckner, B., et al. 2005. Cancer Res.65, 6305.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₉H₁₄N₂O₄
分子量	334.33

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
效能	115 nM IC₅₀
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 100 mg/mL methanol: soluble
运输	ambient
储存温度	2-8℃
InChI	1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)
InChI key	HPTXLHAHLXOAKV-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable