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位置:首页 > 品牌 > Sigma-Aldrich > Brevetoxin PbTx-2, Ptychodiscus brevis-CAS 79580-28-2-Calbiochem

Brevetoxin PbTx-2, Ptychodiscus brevis-CAS 79580-28-2-Calbiochem

品牌
Sigma-Aldrich
CAS
79580-28-2
货号
203732
规格纯度
Lipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes.
参考价格
6950.86 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
79580-28-2
Brevetoxin PbTx-2, Ptychodiscus brevis-CAS 79580-28-2-Calbiochem
Brevetoxin B, GbTx-2
产品介绍:

产品说明

一般描述

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na+ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.
Lipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes. Binds at site 5 on the voltage-sensitive Na+ channel.

包装

100 μg in Glass bottle
yes
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Neurotoxin that binds to Na+ channels on nerves and muscles.

警告

Toxicity: Highly Toxic (H)

重悬

Following reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.





From Catalog:

Solubitlity- removed acetone, EtOAc

其他说明

Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.
Trainer, V.L. 1991. Mol. Pharmacol.40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.
Baden, G. 1989. FASEB J.3, 1807.
Baden, D.G., et al. 1988. Toxicon26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.
Nakanishi, K. 1985. Toxicon23, 473.
Baden, D.G., et al. 1982. Toxicon19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C50H70O14
分子量895.08

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 tan to white
溶解性ethyl acetate: soluble
methanol: soluble
water: soluble
运输wet ice
储存温度−20℃
InChI1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-
InChI keyLYTCVQQGCSNFJU-KTKRTIGZSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H300 + H310 + H330
预防措施声明P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
危险分类Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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