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Gambogic Acid, Garcinia hanburyi-CAS 2752-65-0-Calbiochem

品牌
Sigma-Aldrich
CAS
2752-65-0
货号
345701
规格纯度
A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.
参考价格
2544.41 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
2752-65-0
Gambogic Acid, Garcinia hanburyi-CAS 2752-65-0-Calbiochem
Guttic Acid, β-Guttiferin
产品介绍:

产品说明

一般描述

A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).

包装

25 mg in Alu drum
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Caspase activator and an apoptosis inducer
MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

其他说明

Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769.
Asano, J., et al. 1996. Phytochemistry41, 815.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C38H44O8
分子量628.75

产品性质

质量水平100
测定≥95% (TLC)
形式amorphous solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 orange
溶解性DMSO: 10 mg/mL
ethanol: soluble
运输ambient
储存温度2-8℃
InChI1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1
InChI keyGEZHEQNLKAOMCA-PLUQQRNKSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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