活化7-脱氢胆固醇

产品名称：

67-97-0
Cholecalciferol
Calciol
(+)-Vitamin D₃
7-Dehydrocholesterol activated
Activated 7-dehydrocholesterol
胆钙化醇
活化7-脱氢胆固醇
(+)-维生素 D₃
胆骨化醇
活化7-脱氢胆甾醇

产品介绍：

产品说明

一般描述

Cholecalciferol, also called vitamin D₃, promotes the absorption of calcium and phosphorus in the body to regulate bone growth. It is most commonly found in humans and animals and is produced in our skin when exposed to sunlight. It is used to treat and prevent bone disorders (such as rickets, osteomalacia).

应用

Cholecalciferol has been used as an internal standard in high-performance liquid chromatography (HPLC) to analyze serum vitamin D levels. It has also been used as a standard in liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to quantify vitamin D3 in sunflower oil.
Cholecalciferol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

包装

1, 5 amp in ampule
Packaged in flame-sealed ampules under Argon

生化/生理作用

维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。
Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue. Deficiency of vitamin D is often observed in chronic kidney disease.

基本信息

经验(实验)分子式	C₂₇H₄₄O
分子量	384.64
Beilstein	2339331
EC 号	200-673-2
MDL编号	MFCD00078131
eCl@ss	34058003
PubChem化学物质编号	24893197
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic (organic - wool)
等级	analytical standard
测定	≥97.0%
形式	crystalline
包装	pkg of 250 mg
颜色	white
mp	83-86 ℃ (lit.)
储存温度	2-8℃
SMILES string	CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
InChI	1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key	QYSXJUFSXHHAJI-YRZJJWOYSA-N
Gene Information	human ... VDR(7421)

安全信息

象形图
警示用语：	Danger
危险声明	H300 + H310 + H330 - H372
预防措施声明	P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
危险分类	Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges