Anti-Calcium Channel (α_1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

产品说明

一般描述

The calcium channel, voltage-dependent, N type, α1B subunit (CACNA1B) or Cav2.2 gene consists of 47 exons and 46 introns, spanning 244kb. The gene is mapped to human chromosome 9q34. The encoded protein is a member of the voltage-gated calcium channel family.

免疫原

synthetic peptide corresponding to amino acids 851-867 of the α_1B subunit of rat brain voltage-gated calcium channel (VGCC, CNB1), with additional N-terminal lysine and tyrosine, conjugated to KLH.¹

应用

Anti-Calcium Channel (α1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit has been used in immunofluorescence analysis.
Anti-Calcium Channel (α1B Subunit) (N-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:

• immunocytochemistry using rat brain sections
• immunoprecipitation
• western blotting at a dilution of 1:100-1:200 using rat brain membranes

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)

生化/生理作用

Calcium channel, voltage-dependent, N type, α1B subunit (CACNA1B) plays a vital role in regulation of trafficking and biophysical properties of voltage-gated calcium channels. Members of voltage-gated calcium channel family act as key transducers of cell surface membrane potential changes to local intracellular calcium transients that initiate various physiological events. The N-type voltage-gated calcium channels (VGCCs) expressed mainly in the neurons, facilitate neurotransmitter release at the sympathetic nerve terminals. CACNA1B is expressed on presynaptic nerve terminals of nociceptors control neurotransmitter release.

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD02095951
NACRES	NA.41

产品性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	lyophilized powder
分子量	antigen 210 kDa (low) antigen 240 kDa (high)
species reactivity	rat, mouse
technique(s)	immunocytochemistry: suitable using rat brain sections immunoprecipitation (IP): suitable western blot: 1:100-1:200 using rat brain membranes
UniProt登记号	Q02294
储存温度	−20℃
Gene Information	mouse ... Cacna1b(12287) rat ... Cacna1b(257648)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable