产品说明
一般描述
Note: 1 mU = 1 milliunit.
Recombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase preferentially expressed in macrophages and microglia. Exhibits high specific activity.
Recombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation.
包装
25 μg in Plastic ampoule
警告
Toxicity: Harmful (C)
单位定义
One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
外形
In 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
重悬
Following initial thaw, aliquot and freeze (-70°C).
其他说明
Liuzzo, J.P., et al. 1999. Mol. Med.5, 334.
Riese, R.J., et al. 1998. J. Clin. Invest.101, 2351.
Sukhova, G.K., et al. 1998. J. Clin. Invest.102, 576.
Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol.244, 500.
Xin, X.Q., et al. 1992. Arch. Biochem. Biophys.299, 334.
Kirschke, H., et al. 1989. Biochem. J.264, 467.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 酶学委员会(EC)编号 | 3.4.22.27 ( BRENDA | IUBMB ) |
产品性质
| 质量水平 | 100 |
| 重组 | expressed in E. coli |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | liquid |
| specific activity | ≥30,000 mU/mg protein |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles |
| 运输 | wet ice |
| 储存温度 | −70℃ |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 - H373 |
| 预防措施声明 | P260 - P264 - P270 - P301 + P312 - P314 - P501 |
| 危险分类 | Acute Tox. 4 Oral - STOT RE 2 Oral |
| 靶器官 | Kidney |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
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