缬氨霉素

产品名称：

2001-95-8
Valinomycin
Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
缬氨霉素

产品介绍：

产品说明

一般描述

Chemical structure: peptide

应用

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

包装

5 mL in glass bottle

生化/生理作用

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.
K⁺选择性离子载体环羧酚酸肽；钾离子载体，其可解偶联氧化磷酸化、诱导鼠胸腺细胞凋亡、抑制NGF诱导的神经元分化、并拮抗ET诱导的血管收缩。

其他说明

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

基本信息

经验(实验)分子式	C₅₄H₉₀N₆O₁₈
分子量	1111.32
Beilstein	78657
MDL编号	MFCD00005114
PubChem化学物质编号	24900743

产品性质

质量水平	200
生物来源	Streptomyces sp.
测定	≥90% (HPLC)
形式	liquid
储存条件	(Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
浓度	~1 mg/mL in DMSO
颜色	colorless
作用机制	cell membrane \| interferes
抗生素抗菌谱	Gram-positive bacteria parasites viruses
运输	wet ice
储存温度	2-8℃
SMILES string	CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
InChI	1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
InChI key	FCFNRCROJUBPLU-RPUZOQEISA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - closed cup
闪点(C)	87 ℃ - closed cup
个人防护装备	Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter