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位置:首页 > 品牌 > Sigma-Aldrich > L-S-(3-氨基-3-羧丙基)-S-甲基砜亚胺

L-Methionine sulfoximine

L-蛋氨酸亚砜酰亚胺

品牌
Sigma-Aldrich
CAS
15985-39-4
货号
M5379
包装型号
规格纯度
参考价格
1622.12 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
15985-39-4
L-Methionine sulfoximine
L-S-(3-Amino-3-carboxypropyl)-S-methylsulfoximine
L-蛋氨酸亚砜酰亚胺
L-S-(3-氨基-3-羧丙基)-S-甲基砜亚胺
产品介绍:

产品说明

应用

L-甲硫氨酸亚砜亚胺已被用作谷氨酰胺合成酶(GS)活性的一种有效抑制剂。

包装

250, 500 mg in poly bottle
1, 5 g in poly bottle

生化/生理作用

As a potent inhibitor of glutamine synthetase activity (GS), this reagent has widely been used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. The growing demand for high yield cell banks for production of recombinant proteins for therapeutics has resulted in two major systems for selection of stable and active clones, Methotrexate selection of dihydrofolate reductase (DHFR) overexpressing cells and MSX selection of glutamine synthetase overexpressing cells. Cells are grown in the absence of glutamine in the media and inhibition of the endogenous activity of glutamine synthetase results in cell death for cells lacking overexpression. The MSX-glutamine synthetase selection mechanism provides benefits over that of the Methotrexate-DHFR system in that it typically requires a single amplification step and results in significant reduction of time to produce high stability, highly amplified clones. L-Methionine sulfoximine (MSX) enhances NH3 production in seedling leaves wheat, barley, corn and sorghum plants by inhibiting GS activity. MSX increases ornithine decarboxylase activity and decreases the survival rate in a model of transient cerebral ischemia.

基本信息

线性分子式CH3S(O)(=NH)CH2CH2CH(NH2)CO2H
分子量180.23
Beilstein6175446
MDL编号MFCD00002621
PubChem化学物质编号24278555
NACRESNA.32

产品性质

质量水平300
mp>210 ℃ (dec.) (lit.)
SMILES stringCS(=N)(=O)CC[C@H](N)C(O)=O
InChI1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1
InChI keySXTAYKAGBXMACB-DPVSGNNYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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