5-Aza-CdR, 5-Aza-dC, 2′-Deoxy-5-azacytidine, Decitabine

产品名称：

2353-33-5
5-Aza-2'-Deoxycytidine-CAS 2353-33-5-Calbiochem
5-Aza-CdR, 5-Aza-dC, 2′-Deoxy-5-azacytidine, Decitabine

产品介绍：

产品说明

一般描述

A cytosine analog that acts as a DNA methyltransferase inhibitor. Shown to restore mRNA and protein expression of caspase-8 and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) sensitivity of resistant cell lines. Also reported to enhance apoptosis induced by histone deacetylase (HDAC) inhibitors.
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826).

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
DNA methyltransferase inhibitor

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

制备说明

warming is required to achieve complete solubilization

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₈H₁₂N₄O₄
分子量	228.21
MDL编号	MFCD00043011

产品性质

质量水平	200
测定	≥98% (HPLC)
形式	lyophilized
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
溶解性	methanol: 1 mg/mL 50% acetic acid: 25 mg/mL DMSO: 25 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
InChI key	XAUDJQYHKZQPEU-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H315 - H319 - H335 - H341 - H360
预防措施声明	P201 - P202 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3