5,5-二苯基海因钠盐

产品名称：

630-93-3
5,5-Diphenylhydantoin Sodium Salt
Phenytoin
5,5-Diphenyl-2,4-imidazolidinedione
5,5-二苯基海因钠盐
苯妥英
5,5-联苯基乙内酰脲

产品介绍：

产品说明

一般描述

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

应用

5,5-Diphenylhydantoin sodium salt has been used:

in the cream preparation for treating burn wounds
in seizure behavior testing as an anticonvulsant in Drosophila
in in vivo embryo toxicity test in mouse embryonic stem cells

生化/生理作用

减少癫痫大发作的发生率；可能通过 Na⁺、K⁺ 和 Ca²⁺ 通道的影响而稳定可兴奋膜。

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

线性分子式	C₁₅H₁₁N₂O₂Na
分子量	274.25
EC 号	211-148-2
MDL编号	MFCD00069674
PubChem化学物质编号	24277707
NACRES	NA.77

产品性质

质量水平	200
测定	≥99%
溶解性	aqueous base: soluble
SMILES string	[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI	1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI key	FJPYVLNWWICYDW-UHFFFAOYSA-M
Gene Information	human ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H317 - H361
预防措施声明	P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
危险分类	Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges