2-β-<SC>D</SC>-Ribofuranosyl-1,2,4-triazine-3,5(2<I>H</I>,4<I>H</I>)-dione

产品名称：

54-25-1
6-Azauridine
6-Azauracil riboside
2-β-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione

产品介绍：

产品说明

一般描述

6-Azauridine is a pyrimidine nucleoside analog.

应用

6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.
6-Azauridine has been used:

in uridine monophosphate synthase (UMPS) activity assay
as an antiviral agent to study its inhibition effect and cytotoxic potential on foot and mouth disease virus
to screen for anticryptosporidial activity
in the pretreatment of HeLa cells to study its effect on inhibition of cellular uridine synthesis before and during chase with 5-bromouridine 5′-triphosphate (BrUTP)
as a reference compound for comparing the antiviral activity and cytotoxic activity against viral host cell lines

包装

1, 5 g in poly bottle

生化/生理作用

6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.

基本信息

经验(实验)分子式	C₈H₁₁N₃O₆
分子量	245.19
EC 号	200-199-6
MDL编号	MFCD00006472
PubChem化学物质编号	24890597
NACRES	NA.51

产品性质

测定	≥99% (TLC)
质量水平	200
形式	powder
mp	157-159 ℃ (lit.)
溶解性	water: 50 mg/mL, clear, colorless
储存温度	2-8℃
SMILES string	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2N=CC(=O)NC2=O
InChI	1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/m1/s1
InChI key	WYXSYVWAUAUWLD-SHUUEZRQSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332 - H351
预防措施声明	P201 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Oral - Carc. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves