2,6-二氧六氢-4-嘧啶羧酸

产品名称：

5988-19-2
L-Dihydroorotic acid
L-Hydroorotic acid
Dihydro-L-orotic acid
2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
L-二氢乳清酸
2,6-二氧六氢-4-嘧啶羧酸
L-氢乳清酸
二氢-L-乳清酸

产品介绍：

产品说明

应用

L-Dihydroorotic acid has been used as a substrate in dihydroorotate dehydrogenase (DHODH) assay.

包装

500 mg in poly bottle
1, 5 g in poly bottle

生化/生理作用

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF D7128.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。

基本信息

经验(实验)分子式	C₅H₆N₂O₄
分子量	158.11
MDL编号	MFCD00085339
PubChem化学物质编号	24894080
NACRES	NA.83

产品性质

质量水平	200
测定	≥99%
mp	254-255 ℃ (dec.) (lit.)
SMILES string	OC(=O)[C@@H]1CC(=O)NC(=O)N1
InChI	1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
InChI key	UFIVEPVSAGBUSI-REOHCLBHSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves