产品说明
包装
5, 10, 25, 50, 100 mg in glass bottle
生化/生理作用
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
分析说明
由于三种形式在溶液中达到平衡，亮抑酶肽可在 HPLC 上形成多个峰。通过三个主峰测定纯度。主要的杂质肽为外消旋亮抑酶肽。
基本信息
| 经验(实验)分子式 | C20H38N6O4 · xC2HF3O2 |
| 分子量 | 426.55 (free base basis) |
| MDL编号 | MFCD00133458 |
| PubChem化学物质编号 | 329817397 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 生物来源 | microbial |
| 测定 | ≥90% (HPLC) |
| 形式 | powder |
| 溶解性 | H2O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 ℃.) |
| 储存温度 | −20℃ |
| SMILES string | OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O |
| InChI | 1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1 |
| InChI key | WUHGBZVQELGOMH-FRKSIBALSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
