产品说明
应用
Interferon-αA/D human has been used:
生化/生理作用
Interferon-αA/D (Bg/II), also known as Universal Type I Interferon, is an α interferon hybrid that crosses the species barrier. The Bg/II denotes the restriction enzyme site from which this hybrid is constructed from recombinant human interferons αA and αD. Interferon-αA/D has been proven to be active on many mammalian cells. It can substitute for human, monkey, mouse, bovine, rat, cat, dog, rabbit, sheep, goat, horse, pig or hamster type I interferon (α, β, ω and τ). Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes), and ruminant embryos (τ subtypes). This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
外形
Solution in phosphate buffered saline containing 0.1% bovine serum albumin
分析说明
The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for human interferonαA.
基本信息
MDL编号 | MFCD01635116 |
NACRES | NA.32 |
产品性质
质量水平 | 200 |
生物来源 | human |
重组 | expressed in E. coli |
测定 | ≥95% |
形式 | buffered aqueous solution |
分子量 | 19 kDa |
包装 | pkg of 100K units |
technique(s) | cell culture | mammalian: suitable |
杂质 | endotoxin, tested |
颜色 | colorless |
UniProt登记号 | P01563 |
运输 | dry ice |
储存温度 | −70℃ |
Gene Information | human ... IFNA2(3440) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves |
Sigma-Aldrich