产品说明
一般描述
Dystrophin is a rod-shaped cytoskeletal protein located to the periphery (plasma membrane) of normal striated muscle fibers.
Anti-Dystrophin antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with fragment of recombinant human dystrophin. Dystrophin is a 427 kD protein which joins the actin cytoskeleton to laminin. It possesses multiple domains and is localized to the extracellular matrix. Dystrophin contains NH2-terminal domain for actin binding. The C-terminal domain interacts with dystrophin associated protein (DAP).
特异性
Anti-Dystrophin antibody, Mouse monoclonal specifically recognizes an epitope located on the rod domain of the human dystrophin molecule.
免疫原
recombinant human dystrophin
应用
Anti-Dystrophin antibody, Mouse monoclonal has been used in immunoblotting and immunohistochemistry.
生化/生理作用
Dystrophin is known to prevent muscle fibre injury due to contraction.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.
其他说明
This product is for R&D use only, not for drug, household, or other uses.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | MANDYS8, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~427 kDa |
| species reactivity | human, mouse, porcine, rabbit, rat |
| 浓度 | ~1.0 mg/mL |
| technique(s) | immunoblotting: suitable immunohistochemistry: 5-10 μg/mL using acetone fixed rat tongue frozen sections |
| 同位素/亚型 | IgG2b |
| UniProt登记号 | P11532 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
