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Anti-Fibroblast Growth Factor-Basic antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
F6162
规格纯度
clone FB-8, purified from hybridoma cell culture
参考价格
4731.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Fibroblast Growth Factor-Basic antibody, Mouse monoclonal
Monoclonal Anti-Fibroblast Growth Factor-Basic antibody produced in mouse
Anti-FGF2
产品介绍:

产品说明

一般描述

Anti-Fibroblast Growth Factor-Basic antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the FB-8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Fibroblast growth factors (FGFs) are members of a family of polypeptides. The names FGF acidic and basic are used for FGF-1 and FGF-2, respectively. Acidic and basic fibroblast growth factor (aFGF and bFGF, respectively) are members of a small family of heparin binding growth factors (HBGF). bFGF usually has an apparent mass of about 18 kDa.

特异性

The antibody reacts specifically with both native and recombinant human FGF2. It does not cross-react with human FGF1.

免疫原

recombinant human FGF2.

应用

Anti-Fibroblast Growth Factor-Basic antibody has been used in in immunolabelling and western blotting. It may also be used in:

  • in immunoblotting
  • in enzyme linked immunosorbent assay (ELISA)
  • in dot blot
  • in radio immune assay (RIA)
  • in neutralization bioassays

Used in protein pin array assay to identify the interactive sequences in human αB crystalline protein. The antibody can be used for neutralization of the biological activity of FGF2 in cell culture.

生化/生理作用

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activating pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

外形

Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00212948
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆FB-8, monoclonal
形式buffered aqueous solution
分子量antigen 18 kDa
species reactivitybovine, human
technique(s)dot blot: suitable
indirect ELISA: suitable
neutralization: 5 μg/mL using 1 unit recombinant human FGF2 in mouse 3T3 cells
radioimmunoassay: suitable
western blot: suitable
同位素/亚型IgG1
UniProt登记号P09038
运输dry ice
储存温度−20℃
Gene Informationhuman ... FGF2(2247)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves

Sigma-Aldrich

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