Anti-Frizzled-7 antibody produced in rabbit

产品说明

一般描述

Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD7 is expressed throughout normal gastrointestinal tract, from esophagus to rectum. It is highly expressed in the gastric cancer cell line MKN7 and relatively lowers in esophageal cancer cell lines.

免疫原

synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-7, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.

应用

Anti-Frizzled-7 antibody is suitable for immunostaining of liver tissues to localise FZD7 in T and pT tissues. It is also suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4μg/mL using human kidney.

生化/生理作用

FZD7 shows 98.8% nucleotide identity with FzE3 and encodes for WNT receptors with nine amino-acid substitutions. In human primary gastric cancer, high level of FZD7 has been found. Mechanistically, over-expression of Frizzled-7 accelerates the WNT-β-catenin-TCF pathway. Through the activation of the WNT-β-catenin-TCF pathway, FZD7, might play key roles in carcinogenesis.

外形

Solution in phosphate buffered saline containing 0.01% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质