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Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
H2663
规格纯度
clone HDAC2-62, purified from hybridoma cell culture
参考价格
2067.58 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal
产品介绍:

产品说明

一般描述

Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the HDAC2-62 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the C-terminal region of human histone deacetylase 2 (amino acid residues with N-terminal added cysteine) conjugated to maleimide-activated KLH. Histone deacetylase 2 (HDAC2) is the catalytic subunits of different multiprotein regulatory complexes.

特异性

Monoclonal Anti-Histone Deacetylase 2 (HDAC2) recognizes human, bovine, dog, rat, mouse, and chicken HDAC2 (approx. 55 kDa). The antibody epitope resides within amino acids 471-488 of human HDAC2.

应用

Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal has been used in:

  • co-immunoprecipitation
  • chromatin immunoprecipitation (ChIP)
  • western blot
  • immunohistochemistry
  • enzyme linked immunosorbent assays (ELISA)

包装

200 μL in glass insert

生化/生理作用

Histone Deacetylases including HDAC′s 1-10 facilitate transcriptional repression and nucleosome condensation. Abnormal recruitment of HDACs by various oncoproteins may occur in certain neoplastic diseases. Inhibition of HDAC2 activity by valproic acid induces proteasomal degradation of HDAC2.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02096544
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆HDAC2-62, monoclonal
形式buffered aqueous solution
分子量antigen ~55 kDa
species reactivityrat, canine, human, chicken, mouse, bovine
包装antibody small pack of 25 μL
technique(s)immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 μg/mL using total cell extracts from NIH3T3 cells
同位素/亚型IgG2b
UniProt登记号Q92769
运输dry ice
储存温度−20℃
Gene Informationhuman ... HDAC2(3066)
mouse ... Hdac2(15182)
rat ... Hdac2(84577)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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