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Anti-Cyclophilin B antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200201
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Cyclophilin B antibody produced in rabbit
Anti-SCYLP
Anti-PPIase B
Anti-S-cyclophilin
Anti-PPIB
Anti-rotamase B
Anti-CYP-S1
Anti-cyclophilin-like protein
Anti-CYPB
Anti-peptidyl-prolyl cis-trans isomerase B
Anti-peptidylprolyl isomerase B
Anti-OI9
产品介绍:

产品说明

一般描述

Anti-Cyclophilin B is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human Cyclophilin B conjugated to KLH. Cyclophilin B (CypB) is a 21 kDa protein encoded by the PPIB gene, that belongs to the cyclophilin family, a highly conserved class of proteins originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. CypB is mainly located within the endoplasmic reticulum (ER) of all cell types. CypB is involved in inflammation, viral infection and cancer.

应用

Anti-Cyclophilin B antibody produced in rabbit has been used:

  • immunoblotting
  • immunofluorescence
  • in immunocapture-polymerase chain reaction (PCR) to study the interactions between CypB and Tomato yellow leaf curl virus (TYLCV) coat protein (CP).

生化/生理作用

Cyclophilins are peptidyl-prolyl cistrans isomerases (PPIases) that assist protein folding by catalysing the isomerization of peptidyl-proline bonds. Cyclophilin B (CypB) also plays an important role in protecting cells against ER stress via its PPIase activity. Mutations in the PPIB gene give rise to recessive forms of osteogenesis imperfecta and knockdown of this gene decreases cell growth, proliferation and migration.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02265740
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~20 kDa
species reactivityrat, human, monkey, mouse
浓度~1.0 mg/mL
technique(s)indirect immunofluorescence: 5-10 μg/mL using mouse 3T3 cells
western blot: 0.5-1.0 μg/mL using whole extracts of human HepG2 and rat NRK cells
UniProt登记号P23284
运输dry ice
储存温度−20℃
Gene Informationhuman ... PPIB(5479)
mouse ... Ppib(19035)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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