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Monoclonal Anti-Cytokeratin Peptide 18-FITC antibody produced in mouse

品牌
Sigma-Aldrich
货号
F4772
规格纯度
clone CY-90, purified immunoglobulin, buffered aqueous solution
参考价格
4940.37 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-Cytokeratin Peptide 18-FITC antibody produced in mouse
Monoclonal Anti-Cytokeratin Peptide 18
产品介绍:

产品说明

一般描述

FITC Monoclonal Anti-Cytokeratin Peptide 18 is a purified mouse monoclonal antibody conjugated with fluorescein isothiocyanate (FITC) isomer I. Monoclonal Anti-Cytokeratin Peptide 18 (mouse IgG1 isotype) is derived from the CY-90 hybridoma produced by the fusion of mouse myeloma cells and splenocytes of immunized BALB/c mice. Cytokeratin 18 (CYK18) is a 45 kDa polypeptide, differentially expressed in various human tissues.
Broadly keratins are grouped into two types on the basis of their biochemical and immunological properties: Type II keratins are a family of basic proteins identified as K1 to K8, whereas type I keratins consists of K9 to K20, belong to the acidic group. It belongs to type I acrylic sub-family and is differentially expressed in various human tissues.

免疫原

human epidermal carcinoma A-431 and MCF-7 human breast cancer cell lines.

应用

Monoclonal Anti-Cytokeratin Peptide 18-FITC antibody:

  • is suitable for immunohistochemistry to identify renal tubular epithelial cells in the extrarenal cells regeneration during acute renal failure
  • is suitable for immunocytochemical and immuno-electron microscopic localisation of keratins in human materno-foetal interaction zone
  • may be used for single or double labeling procedures

Monoclonal Anti-Cytokeratin Peptide 18 FITC antibody produced in mouse has been used in:
  • direct immunofluorescent staining
  • immunohistochemistry
  • double immunofluorescence
  • immunocytochemical and immuno?electron microscopic localization of keratins

生化/生理作用

Cytokeratins also called keratins (Ks) according to the new nomenclature system.These are known to be the major structural proteins of epithelial cells. It is heteropolymeric in nature i.e. in cells more than one keratin protein is always present. It belongs to type I acrylic sub-family and is differentially expressed in various human tissues. It maintains the structural integrity of extra-embryonic membrane epithelia. Broadly keratins are grouped into two types on the basis of their biochemical and immunological properties: Type II keratins are a family of basic proteins identified as K1 to K8, whereas type I keratins consists of K9 to K20, belong to the acidic group.
Monoclonal anti-cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. FITC Monoclonal Anti-Cytokeratin Peptide 18 is a chain specific antibody which can facilitate typing of normal, metaplastic and neoplastic cells. Cytokeratin 18 (CYK18) is a cytoskeletal protein associated with apoptosis. CK-18 is considered as a promising plasma biomarker to identify patients with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome.

外形

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA with 15 mM sodium azide as a preservative.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00162250
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物FITC conjugate
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆CY-90, monoclonal
形式buffered aqueous solution
species reactivitywide range
technique(s)direct immunofluorescence: 1:100 using formalin-fixed, paraffin-embedded sections of human or animal tissues
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
同位素/亚型IgG1
运输dry ice
储存温度−20℃

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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