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Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
H6287
规格纯度
clone HDAC1-21, purified from hybridoma cell culture
参考价格
4731.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal
Monoclonal Anti-Histone Deacetylase 1 (HDAC1) antibody produced in mouse
产品介绍:

产品说明

一般描述

Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the HDAC1-21 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human and mouse histone deacetylase 1 (HDAC1).
Histone deacetylases (HDACs) are competing enzymes, belonging to histone deacetylase family. There are two classes of HDACs with six to seven different types of HDACs proteins. HDAC1,HDAC2 and HDAC3 belong to Class I HDACs and HDAC4, HDAC6, and HDAC7 belong to Class II HDACs. Class I HDACs consists of a single deacetylase domain at the N-termini and diversified C-terminal regions, while Class II contains a deacetylase domain at C-terminal position.

应用

Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal has been used in:

  • enzyme-linked immunosorbent assay (ELISA)
  • immunoprecipitation
  • immunoblotting

生化/生理作用

HDAC1 is widely studied and is shown to actively modulate the eukaryotic chromatin structure. It deacetylyses lysine residues on core histones (H2A, H2B, H3 and H4) at the N-terminal. It is a vital component of cofactor complexes and is involved in transcription regulation. Histone deacetylation results in transcription repression leading to the formation of tight nucleosomal structure which prevents DNA accessing.

外形

solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01633420
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆HDAC1-21, monoclonal
形式buffered aqueous solution
分子量antigen ~65 kDa
species reactivitymouse, human
浓度~2 mg/mL
technique(s)immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using total cell extracts of HeLa cells
同位素/亚型IgG3
UniProt登记号Q13547
运输dry ice
储存温度−20℃
Gene Informationhuman ... HDAC1(3065)
mouse ... Hdac1(433759)

Sigma-Aldrich

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