产品说明
特异性
The antibody does not detect endogenous levels of Fe65.
免疫原
synthetic peptide corresponding to amino acid residues 352-369 from mouse Fe65.
应用
Anti-Fe65 antibody produced in rabbit is suitable for western blotting using mouse brain lysate.
生化/生理作用
Amyloid β A4 precursor protein-binding family B member 1 is a protein encoded by the APBB1 gene in humans and is mapped on human metaphase chromosomes to band 11p15. Fe65 is a neuronal adaptor protein that is involved in brain development, Alzheimer disease amyloid precursor protein (APP) signaling and proteolytic processing of APP. It participates in various processes by recruiting various interacting partners to form functional complexes and acts as a novel regulator of neurite outgrowth. Fe65 significantly alters actin dynamics and mitochondrial function in neuronal cells.
外形
Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
基本信息
MDL编号 | MFCD06798441 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 200 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
分子量 | antigen 97 kDa |
species reactivity | mouse |
technique(s) | western blot: suitable using mouse brain lysate |
UniProt登记号 | Q9QXJ1 |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | mouse ... Apbb1(11785) |
Sigma-Aldrich