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Anti-Estrogen Receptor (18-32) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
E0521
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
5757.85 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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产品名称:
Anti-Estrogen Receptor (18-32) antibody produced in rabbit
产品介绍:

产品说明

一般描述

Estrogen is a sex hormone that is a key regulator of growth, differentiation and function of reproductive tissues, skeletal and cardiovascular systems. The effect of estrogen is mediated by two intracellular receptors, ERα and ERβ. Although the two receptors interact with similar ligands, have identical DNA-binding domains and have redundant roles in estrogen signaling, they show distinct expression pattern. On binding to the receptor, the estrogen-ER complex enters nucleus and regulates the transcription of specific genes. The biological effects of estrogen and ER is by upstream activation of the pathway by growth factors. Some pathways that activate the estrogen-ER pathway are those mediated by AP-1, IGF-1, EGF, MAPK and PI3K/Akt . Anti-Estrogen Receptor (18-32) antibody is specific for 18-32 amino acids of human estrogen receptor (67 kDa). The product is an IgG fraction prepared from pooled antisera.

免疫原

synthetic peptide corresponding to amino acids 18-32 of the human estrogen receptor.

应用

Anti-Estrogen Receptor (18-32) antibody may be used for immunoblotting using extracts of MCF7 cells at a working dilution of 1:3000. It may also be used for dot blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

外形

Solution in 0.01 M phosphate buffered saline, pH 7.2, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00676446
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 67 kDa
species reactivityhuman
technique(s)microarray: suitable
western blot: 1:3000 using MCF7 cultured cell line extract
UniProt登记号P03372
运输dry ice
储存温度−20℃
Gene Informationhuman ... ESR1(2099)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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