Monoclonal Anti-MUC2 antibody produced in mouse

产品说明

一般描述

The MUC2 (mucin 2, oligomeric mucus/gel-forming) protein belongs to the mucin protein family. It is an important mucin released in the large intestine. It is approximately a 550 kDa protein that has two PTS-domains, rich in proline, serine, and threonine. MUC2 is located on human chromosome 11p15.
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. (provided by RefSeq)

免疫原

MUC2 (NP_002448, 5081 a.a. ~ 5179 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
TTEVSYAGCTKTVLMNHCSGSCGTFVMYSAKAQALDHSCSCCKEEKTSQREVVLSCPNGGSLTHTYTHIESCQCQDTVCGLPTGTSRRARRSPRHLGSG*

生化/生理作用

Mucin 2, oligomeric mucus/gel-forming (MUC2) modulates the expression and antimicrobial activity of β-defensin 2. It acts as a major constituent of the two-layered mucous structure in the colon. Deficiency of MUC2 might lead to opportunistic microbial invasion and/or impaired innate responses.

外形

Solution in phosphate buffered saline, pH 7.4

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