Human IgG, Fab Fragment, Plasma

产品说明

一般描述

Immunoglobulin G (IgG) is the most crucial glycoprotein antibody. It has the longest serum half-life compared to other immunoglobulins. IgG is present in human serum and also identified in the bloodstream. It contains four polypeptide chains, wherein the light and heavy chains are linked by disulfide bonds.

应用

Human IgG, Fab Fragment, Plasma has been used in enzyme-linked immunosorbent assay (ELISA).

包装

2 mg in Plastic ampoule

生化/生理作用

Immunoglobulin G (IgG) initiates the classical pathway of the complement system and eliminates virus particles and toxins. It controls antibody-dependent cell-mediated cytotoxicity (ADCC) and might be correlated to allergy. Digestion of IgG by papain generates fragment antigen-binding (Fab) whereas pepsin digestion of IgG releases crystallizable (Fc) fragment and a single dimeric F(ab)₂.  Maternal IgG is transferred to the fetus via the placenta and is crucial for the immune defense of the neonate against infections. IgG levels in severe acute respiratory syndrome coronavirus (SARS-CoV)2 infected patients may be useful to understand the severity and prognosis of coronavirus disease 2019 (COVID-19).  

警告

Toxicity: Standard Handling (A)

外形

In 150 mM NaCl, 20 mM sodium phosphate buffer, 0.05% NaN₃, pH 7.4.

制备说明

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies of HIV and HCV.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

产品性质

安全信息