产品说明

一般描述

A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; K_i = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice.
A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; K_i = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.

包装

2 mg in Glass bottle
Packaged under inert gas

外形

A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.

重悬

Following intial thaw, aliquot and freeze (-20°C).

其他说明

Yu, P.B., et al. 2008. Nat. Chem. Biol4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970.
Lee, M., et al. 2003. J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003. Cell115, 577.
Fryer, L.G., 2002. FEBS Lett.531, 189.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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