InSolution ATM Kinase Inhibitor

产品说明

一般描述

A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC₅₀ = 13 nM; K_i = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC₅₀ = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC₅₀ >100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.

包装

2 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol.7, 493.
Hickson, I., et al. 2004. Cancer Res.64, 9152.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质