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InSolution PI-103

品牌
Sigma-Aldrich
货号
528101
包装型号
规格纯度
参考价格
3945.15 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
InSolution PI-103
mTOR Inhibitor V, PI 3-K Inhibitor V
产品介绍:

产品说明

一般描述

A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.

包装

2 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Raynaud, F.I., et al. 2007. Cancer Res.67, 5840.
Fan, Q.W., et al. 2006. Cancer Cell9, 341.
Knight, Z.A., et al. 2006. Cell125, 733.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H16N4O3
分子量348.36

产品性质

质量水平100
测定≥97% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
运输wet ice
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

Sigma-Aldrich

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